![]() In general, the water solubility of uric acid and its alkali metal and alkaline earth salts is rather low. ![]() Uric acid is a diprotic acid with p K a1 = 5.4 and p K a2 = 10.3, thus at physiological pH, it predominately exists as the monoionic urate ion. Although the lactim form is expected to possess some degree of aromaticity, uric acid crystallizes in the lactam form, with computational chemistry also indicating that tautomer to be the most stable. Uric acid displays lactam–lactim tautomerism (also often described as keto–enol tautomerism ). ![]() In 1882, the Ukrainian chemist Ivan Horbaczewski first synthesized uric acid by melting urea with glycine. Uric acid was first isolated from kidney stones in 1776 by Swedish chemist Carl Wilhelm Scheele. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions, including diabetes and the formation of ammonium acid urate kidney stones. ![]() Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5H 4N 4O 3.
0 Comments
Leave a Reply. |